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Chapter-06 Angiogenesis

BOOK TITLE: Drug Screening Methods: Preclinical Evaluation of New Drugs

Author
1. Sengupta Shiladitya
ISBN
9788184486186
DOI
10.5005/jp/books/10244_6
Edition
2/e
Publishing Year
2009
Pages
16
Author Affiliations
1. Harvard Medical School, Brigham and Women’s Hospital, MIT, Rm 317, 65 Landsdowne Street, Cambridge, MA (USA), 16-561, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA, Harvard Medical School, Brigham and Women’s Hospital, MIT, Rm 317, 65 Landsdowne Street, Cambridge, MA, USA
Chapter keywords

Abstract

In 1991, Judah Folkman, was the first to propose that tumor growth and metastasis correlate with the extent of angiogenesis or vasculogenesis. Tissue excision, sponge implant, matrigel, disc assay are some of the model systems that are currently being used. Hamster cheek pouch, cornea micropocket, mesentery model, chamber and rat dorsal air sac, chick chorioallantoic membrane models provide important information while screening of drugs.

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