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Chapter-04 Transepithelial Corneal Cross-linking: Technique and Results

BOOK TITLE: Keratoconus Surgery and Cross-linking

Author
1. Pinelli Roberto
2. Leccisotti Antonio
3. Beltagi Tarek El
ISBN
9788184486506
DOI
10.5005/jp/books/10434_4
Edition
1/e
Publishing Year
2009
Pages
8
Author Affiliations
1. Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, 70, 25124 Brescia, Italy, Istituto Laser Microchirurgia Oculare Crystal Palace, Via Cefalonia 70 25124, Brescia, Italy, European School for Advanced Studies in Ophthalmology (ESASO), Universitá della Svizzera Italiana, Lugano, Switzerland, Microchirurgia Oculare, Crystal Palace, Suite, Via Cefalonia, 70 25124 Brescia - Italy, Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, 70, Brescia, Italy, Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, Brescia, Italy, www.ilmo.it, Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, Brescia, Italy, Instituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, Brescia, Italy, Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, 70, 25124, Brescia, Italy, Istituto Laser Microchirurgia, Oculare Crystal Palace, Via Cefalonia, 70, 25124, Brescia, Italy, Crystal Palace Via Cefalonia, 70 25124 Brescia, Italy, Istituto Laser
2. Casa di Cura Rugani, Siena, Italy, Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, 70, 25124 Brescia, Italy
3. Research Institute of Ophthalmology, Cairo, Egypt
Chapter keywords

Abstract

Cross-Linking indicates a medical intervention; first it was used in dentistry and orthopedics. Theo Seiker, MD, was the fist who decided to apply this principle to ophthalmology: Cross-Linking Corneal collagen fibers using riboflavin and UV radiation. Initially, corneal collagen cross-linking required re-epithelization to improve riboflavin penetration in stroma, now it is performed with or without re-epithelization, but it must be remembered that re-epithelization causes a lot of complications. Leaving the epithelium intact it is observed that there no limitation of the penetration of riboflavin. The penetration of riboflavin through intact epithelium can be enhanced by substances increasing its permeability. Dr. Pinelli have patented a riboflavin formula, which is at the present time under investigation on rabbit eyes. Dr. Pinelli believes that in the near future transepithelial method will be a new way to treat keratoconus. Avoiding re-epithelization means avoiding discomfort. A bilateral option may be more accepted by patients. In the future C3R will be less invasive, painless and without re-epithelization. The results of this technique are very encouraging.

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