This chapter discusses various aspects of regional injuries. Craniocerebral injuries, soft tissue injury, skull fractures, coup and contre-coup injury, brain injury, diffuse axonal injury (DAI), cerebral contusion and laceration, subdural hematoma (SDH), and intracerebral hematoma, are some topics discussed in detail. Fractures of the hyoid bone or thyroid cartilage may occur due to fall injuring the neck, or when the neck comes in forcible contact with the handlebar of a cycle or the dashboard of a motor car. The intestinal wound may be situated at some distance from the external wound due to the compression and mobility of the intestines, and the depth of the wound is greater than the length of the penetrating object. Fracture produced just before death or just after death will have similar characteristics, except in the former there may be comparatively greater effusion of blood which will infiltrate the surrounding tissues. Repeated blows on the head may produce small degenerative changes in the region of corpus straitum and thalamus.