This chapter discusses explosion injuries in detail. Mechanism of action of an explosion, general injuries, regional injuries, and investigation of bombing incidents, are some topics discussed in detail. When the body is impacted by a blast pressure wave, it couples into the body and sets up a series of stress waves which are capable of injury, particularly at airfluid interfaces. The most common urgent clinical problem in survivors of explosions is usually the penetrating injury caused by blast-energized debris and fragments from the casing of the exploding device. Regional injuries may include auditory system, respiratory system, GIT, and eye. There may he rupture of the tympanic membrane, dislocation of the ossicles or widespread disruption of the inner ear. Factors that increase the mortality from blast injuries are associated chemical and thermal burns, falling masonry and inhalation of toxic gases and smoke. Triad of bruises, abrasions and puncture lacerations with tattooing of the body indicates bomb explosion. Death due explosions may result from various causes such as complete disintegration of body, blast shock, burns, blunt force injuries and crush asphyxia.