This chapter discusses various non-metallic and mechanical irritants such as phosphorus. It is a protoplasmic poison and affects cellular oxidation. The metabolism of cells reduces, leading to necrobiosis, which is predominantly seen in the liver. Ingestion of phosphorus produces burning pain in the throat and abdomen, with intense thirst, nausea, vomiting, diarrhea and abdominal pain. For the treatment, vitamin K 20 mg. I. V. in repeated doses or blood transfusion. Transfusion of glucose-saline and plasma with vitamins is useful to protect the liver and to correct shock and dehydration. Multiple hemorrhages are seen in the muscles, serosal and mucosal membranes of the GIT and respiratory tract, liver, kidneys, endocardium, pericardium, epicardium, peritoneum, lungs and brain. The frequent inhalation of fumes over a period of years causes necrosis of the lower jaw in the region of a decayed tooth. Of all the mechanical irritants, glass and diamond powder and pointed metallic chips may be of real danger in most cases. Bulky foods such as bananas or rice for easy passage of the glass pieces, is a sure treatment option.