This chapter discusses various aspects of autopsy room hazards. The autopsy room is a potential source of infection and the forensic pathologists and other persons in close proximity to an autopsy are at higher risk of contracting infectious diseases from the dead bodies. Commonly acquired infections include hepatitis b, needle stick injuries, viral hemorrhagic fever (VHF), tuberculosis, and HIV infection. Autopsy of HIV positive and HBV Patients includes a simple and rapid test in which the body should be transported to the mortuary by duly plugging all the natural orifices and sites of the I. V. drip. No unauthorized person, other than experts and workers who are trained in handling the infected material, should be admitted in the autopsy room, so as to minimize exposures. Immunosuppressed or immunodeficient individuals and individuals who have uncovered wounds, oozing skin lesions or dermatitis should not perform the autopsy. All soiled gauze and cotton should be collected in a double plastic bag for incineration. Small spatters and spills of blood and other body fluids should be wiped up with disposable tissues or towels.