Graft reperfusion during orthotopic liver transplantation is generally associated with a variety of transient haemodynamic disturbances. Post-reperfusion syndrome (PRS) is defined as a decrease in mean arterial pressure to >30% below the baseline value for at least 1 minute, occurring during the first 5 minutes after reperfusion. PRS presents as systemic hypotension and pulmonary hypertension. PRS occurs in 15% to 30% of cases, resulting in intense hemodynamic instability. Many potential mechanisms for the haemodynamic changes in PRS have been proposed including sudden influx of cold, acidic, and hyperkalemic blood, minute air and thrombotic embolisation, release of vasoactive substances (Arginine and Thromboxane A2) from the graft and prolonged cold ischemic time.