There are different methods to obtain a liver biopsy. In patients with abnormal coagulation profile, coagulopathy may be corrected by transfusion of fresh frozen plasma and platelets. Cryoprecipitate requirement is unusual. Different approaches for liver biopsy are percutaneous biopsy, transjugular liver biopsy, open needle liver biopsy and laparoscopic liver biopsy. The issue of whether or not to perform a liver biopsy on all potential right lobe liver donor candidates remains controversial. Those favouring mandatory biopsy consider it to be the ‘gold standard’ for evaluation of liver disease. The complication rate associated with liver biopsy has been estimated at 1–2%. Some reports mention that less incidence of occult liver disease in the general population and argue against including biopsy in all work ups. Currently, there are no specific recommendations regarding the need for preoperative liver biopsy in potential live liver donors. The use of liver biopsy in well-selected potential right lobe live donors results in minimal risk to the affected individuals.