JaypeeDigital

Speciality

TESTIMONIALS

NEWSLETTERS

Subscribe to be the first to know about Best Deals and Exclusive Offers!

EXPORT CITATION

Chapter-05 Oxidative Stress and the Pathogenesis of Endometriosis

BOOK TITLE: Endometriosis: Current Management and Future Trends

Author
1. Gupta Sajal
2. Chandra Anjali
3. Kesavan Shubhangi
4. Eapen Deborah
ISBN
9788184488081
DOI
10.5005/jp/books/11032_5
Edition
1/e
Publishing Year
2010
Pages
9
Author Affiliations
1. Glickman Urological and Kidney Institute and Obstetrics-Gynecology and Women’s Health Institute; leveland Clinic, Cleveland, USA, Reproductive Research Center, Glickman Urological and Kidney; Institute, Cleveland Clinic, Cleveland, Ohio, USA, Women’s Health Institute, 9500 Euclid Avenue, A19.1, Cleveland Clinic, Cleveland, Ohio 44195, United States, Center for Reproductive Medicine, Glickman Urological and Kidney, Cleveland Clinic, Cleveland, OH, USA
2. Center for Reproductive Medicine, Glickman Urological and Kidney Institute and Obstetrics-Gynecology and Women’s Health Institute; Cleveland Clinic, Cleveland, USA, Cleveland Clinic 9500 Euclid Avenue, Desk A19.1 Cleveland, Ohio, 44195 USA
3. Center for Reproductive Medicine, Glickman Urological and Kidney Institute and Obstetrics-Gynecology and Women’s Health Institute; Cleveland Clinic, Cleveland, USA
4. Center for Reproductive Medicine Glickman Urological and Kidney Institute and Obstetrics-Gynecology and Women’s Health Institute Cleveland Clinic, Cleveland, USA
Chapter keywords

Abstract

Oxidative stress plays an integral role in the pathogenesis of endometriosis resulting from increased free radical generation and/or decreased levels of scavenging antioxidants. Whether there is a cause–effect relationship between free radical excess and the pathophysiology of these conditions or a temporal one remains to be demonstrated. Regardless, it appears reasonable to investigate the role of antioxidant agents in both the prevention and treatment of endometriosis. They may help ameliorate the extent of lesions and help reduce the severity of symptoms and any subsequent complications that develop. Thus, the identification of OS markers or markers of altered immune function such as IL-6, TNF-alpha, IL-8, IL-1 beta and PON-1 in the serum and peritoneal fluid as a noninvasive option for diagnosing the disease and gauging its severity is important but is still investigational. Further, iron overload contributes to the development of endometriosis by promoting epithelial cell proliferation, and the role DFO plays in inhibiting lesion growth represents an exciting new avenue of research.

Related Books

3988 eBooks
11920 Videos
80651 MCQs
91 eJournals

© 2019 Jaypee Brothers Medical Publishers (P) LTD.   |   All Rights Reserved