Maternal and prenatal genetic is one of the most important health promotion, maintenance and treatment field of the genetics. Maternal infections during pregnancy are known to cause deleterious effect on health and development of growing fetus. In case of any infection, host response in form of increased level of cytokines and chemokines. It is observed in various studies that increased level of maternal serum Cytokines interlukin-8 (IL-8) during second trimester can increase the risk of schizophrenia among offspring. \'TORCH\' infections generally refer to a group of maternally acquired communicable diseases that include Toxoplasmosis, Other (varicella, Venezuelan equine encephalitis, mumps, coxsackie, parvovirus, HIV), Rubella, Cytomegalovirus and Herpes. These infections are well known to cause harmful effect on developing fetus. Further, consanguineous marriage, increased maternal age, exposure of mother to drugs, chemicals, radiations and specific foods also may have fetotoxic effect. Therefore, maternal exposure to teratogens must be prevented and prenatal genetic tests may be carried out if needed. Prenatal tests may include invasive tests such as ultrasound, fetal echocardiography, fetal radiology; and invasive tests such as amniocentesis, chorionic villus sampling, fetal blood sampling, maternal blood sampling, fetal tissue sampling and fetoscopy etc. in addition, if applicable and possible reimplementation prenatal diagnosis also may be practiced. Newer advancements have identified that infertility and spontaneous abortions are found to be having genetic basis. Therefore, diagnosis and management of the infertility and spontaneous abortions may be based on the available genetic information. Neural tube defects, Down\'s syndrome are the most common genetics disorders, which are preventable and manageable through prenatal genetic diagnosis and management.