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Chapter-22 Effects of Natural Polyphenols on Chemoradiotherapy in Cancer

BOOK TITLE: Herbal Medicine: A Cancer Chemopreventive and Therapeutic Perspective

Author
1. Garg Amit K
2. Buchholz Thomas A
3. Aggarwal Bharat B
ISBN
9788184488418
DOI
10.5005/jp/books/11166_22
Edition
1/e
Publishing Year
2010
Pages
22
Author Affiliations
1. The University of Texas, MD Anderson Cancer Center, Hocomb Boulevard, Houston, USA
2. The University of Texas MD Anderson Cancer Center, Hocomb Boulevard, Houston, USA
3. The University of Texas MD Anderson Cancer Center, Hocomb Boulevard, Houston, USA
Chapter keywords

Abstract

Chemotherapeutic agents and radiation are established treatment modalities for many tumor types. However, the development of tumor resistance to therapy (chemoresistance and radioresistance) and non-specific toxicity toward normal cells remains a major obstacle. Most studies involving plant-derived polyphenols have focused on their potential chemopreventive properties but only relatively recently have many natural polyphenols been shown to sensitize tumor cells to chemotherapy and radiation through the inhibition of pathways that lead to treatment resistance. Notable examples include curcumin, genistein, resveratrol, caffeic acid phenethyl ester, flavopiridol, and green tea polyphenols. Furthermore, studies, suggest that plant polyphenols may also hold value in preventing or alleviating therapy-related side effects through pathways linked to inflammation.

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