Different variants of endokeratoplasty with creation of a flap (FDLEK) or without as Posterior Lamellar Keratoplasty (PLK), Deep Lamellar endothelial keratoplasty (DLEK), Descemet Stripping Endothelial Keratoplasty (DSEK), Descemet Stripping Automated Endothelial Keratoplasty (DSAEK), Descemet’s membrane endothelial keratoplasty (DMEK) are still developing. Femtosecond laser technology seems to be one of the most promising tools in ophthalmic surgery. Several groups are working on its application on endokeratoplasty where it can be used to cut both the donor and recipient. Case reports contain reports of two patients. The first case states pseudophakic bullous keratopathy in 64 years old female patient with history of Fuchs Endothelial Dystrophy. The patient undergoes cataract surgery six months ago. Both eyes develop chronic corneal edema after surgery. The second case states about a sixty four years old male patient who is operated for cataract eight months ago. The patient has history of Fuchs endothelial dystrophy. The patient has severe bullous keratopathy. Compared to Penetrating Keratoplasty, Endokerato-plasty has the advantage of a better quality and faster recovery of visual acuity. The risk of global rupture is drastically decreased. The time and amount of open eye during surgery is less and lower risk of serious surgical complications.