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Chapter-32 Intracorneal and Intracameral Amphotericin B in Fungal Corneal Ulcers

BOOK TITLE: Surgical Techniques in Ophthalmology: Corneal Surgery

Author
1. Sharma Ashok
ISBN
9788184488579
DOI
10.5005/jp/books/11369_32
Edition
1/e
Publishing Year
2010
Pages
4
Author Affiliations
1. Dr Ashok Sharma’s Cornea Centre, Sector 22-A, Opp. Parade Ground, Near Bus Stand, Chandigarh, India, Dr Ashok Sharma’s Corneal Centre, SCO 833-834, 2nd Floor, Sector 22-A, Chandigarh, India, Cornea Centre, SCO 833-834 (2nd Floor), Sector 22-A, Near Bus Stand, Opp Parade Ground, Chandigarh, India, Dr. Ashok Sharma’a Cornea Centre, SCO 833-34 (2nd Floor), Sector 22-A, Opp. Parade Ground, Near Bus Stand, Chandigarh, India, Dr Ashok Sharma’s Cornea Centre, Chandigarh, India, Dr. Ashok Sharma’s Corneal Centre, SCO 833-834 (2nd Floor), Sector 22-A, Chandigarh, India, Dr. Ashok Sharma’s Cornea Center, SCO 833-34 (2nd Floor), Sector 22-A Opp. Parade Ground, Near Bus Stand, Chandigarh, India, Malhotra Test Tube Baby Centre, Agra, Indra Gandhi Medical College, Shimla, Himachal Pradesh, India, Scientific Pathology Laboratories, Agra, Uttar Pradesh, India, Dr Ashok Sharma’s Cornea Centre, SCO 833-834, IInd Floor Sector 22-A, Chandigarh, India
Chapter keywords
infective keratitis, ocular morbidity, corneal blindness, keratomycosis, penetrating keratoplasty, intracameral and intra-corneal injections, fungal keratitis, amphotericin B, resistant keratomycosis

Abstract

Infective keratitis is a major cause of ocular morbidity and corneal blindness in the developing world. Those patients suffering from severe keratomycosis and not responding to topical and systemic antifungal drugs require emergency penetrating keratoplasty to eliminate infection and at times to save the integrity of eye. Intracameral and intra-corneal injections offer several advantages in the management of fungal keratitis. Injection provides maximum concentrations of the drug at desired site instantaneously. Intracameral and intracorneal injections provide rapid, safe, effective, convenient and economical option. Results of study indicate that intra-cameral and intra-corneal infections of amphotericin B may be considered an alternate option to surgical intervention in resistant keratomycosis.

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