Mooren’s ulcer is a chronic, bilateral, progressive, painful, peripheral corneal ulceration. The disease progresses circumferentially initially, radially towards center and into the deeper corneal stroma at later stage of the disease. Several predisposing factors including previous trauma, history of surgical procedure and infections are found to be associated with the onset of the disease. The exact etiopathogenesis remains unknown. Autoimmune mechanisms are postulated to be the underlying cause of the disease. The diagnosis of Mooren’s ulcer is based on its classical clinical appearance and exclusion of various systemic disorders associated with development of peripheral ulcerative keratitis. All patients suffering from Mooren’s ulcer should be subjected to detailed microbiological work up. In case a micro-organism is isolated, broad spectrum antibiotic should be given. The mainstay of the treatment is oral corticosteroids. Topical steroids, topical antibiotic and cycloplegic are prescribed in all cases. The resolution of the corneal infiltrate and healing of corneal epithelial defect indicate that the Mooren’s ulcer is responding. Patients developing vascularization of the cornea approaching the margin of the ulcer should be considered for repeat peritectomy, otherwise the patient will develop recurrence of the disease.