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Chapter-48 Amniotic Membrane Transplantation as an Alternative to Keratoplasty

BOOK TITLE: Corneal Transplantation

Author
1. Vajpayee Rasik B
2. Chawla Bhavna
ISBN
9788184488593
DOI
10.5005/jp/books/11167_48
Edition
2/e
Publishing Year
2010
Pages
6
Author Affiliations
1. RP Center of Ophthalmology, AIIMS, Ansari Nagar, New Delhi 110 029, India, Dr RP Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, Centre for Eye Research, Australia, Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia, Centre of Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia, Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, Dr Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Center for Eye Research Australia, University of Melbourne, Melbourne, Australia, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, RP Center of Ophthalmic Sciences, AIIMS, Ansari Nagar, New Delhi, India~
2. Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
Chapter keywords

Abstract

Amniotic membrane transplantation is a safe, effective, and long-lasting therapeutic modality for patients with chronic bullous keratopathy. It can alleviate pain, promote corneal epithelialization, reduce conjunctival inflammation and may also improve visual acuity in some cases, obviating the need for a keratoplasty. Amniotic membrane transplantation has a valuable role in the management of neurotrophic corneal ulcers and Mooren’s ulcers which are refractory to conventional therapy. In cases with impending and small corneal perforations, Amniotic membrane transplantation leads to a rapid reconstruction of the corneal surface and can give a good final functional result. Thus, it is a good alternative to avoid or delay penetrating keratoplasty especially in acute cases in which graft rejection risk is high. Amniotic membrane transplantation has also been found to be effective in limiting stromal loss and preventing corneal perforations and the need for a therapeutic keratoplasty in selected cases of acute infectious keratitis. To summarize, the ‘keratoplasty-sparing’ role of Amniotic membrane transplantation cannot be overemphasized. This is particularly relevant in our scenario in the face of limited availability of donor corneal tissue.

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