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Chapter-17 Selenium: Correlation with Glaucoma

BOOK TITLE: Nutrition and the Eye

Author
1. Pinelli Roberto
2. Elborgy Ebrahim
ISBN
9788184488623
DOI
10.5005/jp/books/11052_17
Edition
1/e
Publishing Year
2010
Pages
3
Author Affiliations
1. Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, 70, 25124 Brescia, Italy, Istituto Laser Microchirurgia Oculare Crystal Palace, Via Cefalonia 70 25124, Brescia, Italy, European School for Advanced Studies in Ophthalmology (ESASO), Universitá della Svizzera Italiana, Lugano, Switzerland, Microchirurgia Oculare, Crystal Palace, Suite, Via Cefalonia, 70 25124 Brescia - Italy, Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, 70, Brescia, Italy, Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, Brescia, Italy, www.ilmo.it, Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, Brescia, Italy, Instituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, Brescia, Italy, Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, 70, 25124, Brescia, Italy, Istituto Laser Microchirurgia, Oculare Crystal Palace, Via Cefalonia, 70, 25124, Brescia, Italy, Crystal Palace Via Cefalonia, 70 25124 Brescia, Italy, Istituto Laser
2. Research Institute of Ophthalmology, Giza, Egypt
Chapter keywords

Abstract

Selenium-induced changes in MMP-2/TIMP-1 secretion may cause an increase in intraocular pressure that eventually leads to glaucoma. Selenium is an essential element found in many foods and recently has been founded as a nutrition supplement with chemopreventive properties, but there is a an incidence of glaucoma in some participants who received selenium supplements. Glaucoma is the second leading cause of irreversible blindness in the United States, it is characterized by death of retinal ganglion cells with consequent increased intraocular pressure resulting from a decrease in aqueous humor outflow. Several forms of selenium exist and are used for supplementation. It is observed an increase in the risk of glaucoma associated with above-average selenium intake, however, further research is needed to make firm conclusion about causality and to identify doses of selenium that retain beneficial properties without inducing ocular toxicity.

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