EXPORT CITATION

Chapter-09 Role of Dietary Supplements in the Prevention and Progression of AMD

BOOK TITLE: Nutrition and the Eye

Author
1. Pinelli Roberto
2. Elborgy Ebrahim
ISBN
9788184488623
DOI
10.5005/jp/books/11052_9
Edition
1/e
Publishing Year
2010
Pages
21
Author Affiliations
1. Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, 70, 25124 Brescia, Italy, Istituto Laser Microchirurgia Oculare Crystal Palace, Via Cefalonia 70 25124, Brescia, Italy, European School for Advanced Studies in Ophthalmology (ESASO), Universitá della Svizzera Italiana, Lugano, Switzerland, Microchirurgia Oculare, Crystal Palace, Suite, Via Cefalonia, 70 25124 Brescia - Italy, Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, 70, Brescia, Italy, Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, Brescia, Italy, www.ilmo.it, Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, Brescia, Italy, Instituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, Brescia, Italy, Istituto Laser Microchirurgia Oculare, Crystal Palace, Via Cefalonia, 70, 25124, Brescia, Italy, Istituto Laser Microchirurgia, Oculare Crystal Palace, Via Cefalonia, 70, 25124, Brescia, Italy, Crystal Palace Via Cefalonia, 70 25124 Brescia, Italy, Istituto Laser
2. Research Institute of Ophthalmology, Giza, Egypt
Chapter keywords

Abstract

Age-related macular degeneration (AMD) is the major cause of legal blindness for older white adults in Australia, Western Europe, and North America, and studies have provided strong evidence that the disease is caused by the actions and interactions of multiple genetic and environmental factors. In 2001 AREDS a randomized, placebo controlled trial shoes that high-dose supplement of vitamin C, E, b-carotene, and zinc was protective against progression of moderately severe early AMD to advanced AMD. Two carotenoids, lutein and zeaxanthin, where considered for inclusion in the formulation during the planning phase because they are concentrated in the macula. b-carotene, another carotenoid with antioxidant potential, was included because it was readily available and undern investigation in clinical trials of heart disease and cancer. Vitamin D is a potent inhibitor of angiogenesis by its effects on endothelial cells and by interrupting signalling pathways that are key to angiogenesis, specifically in tumori genesis. By virtue of its antiangiogenic role, vitamin D may protect against ‘’wet’’ advanced AMD, which involves growth of new blood vessels in the retina.

© 2019 Jaypee Brothers Medical Publishers (P) LTD.   |   All Rights Reserved