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Chapter -03 Understanding the Physiology of Fertilization

BOOK TITLE: Andrology Laboratory Manual

Author
1. Agarwal Ashok
2. Luu Andrew
ISBN
9788184489019
DOI
10.5005/jp/books/11172_3
Edition
1/e
Publishing Year
2010
Pages
9
Author Affiliations
1. Cleveland Clinic Lerner College of Medicine, Case Western Reserve University Staff, Glickman Urological and Kidney Institute, Ob-Gyn and Women’s Health Institute, Anatomic Pathology and Immunology Cleveland Clinic, Desk A 19.1 Cleveland, Ohio, USA, Clinical Andrology Center and Fertility Laboratory; Research at the American, Center for Reproductive Medicine, Cleveland Clinic, Cleveland, USA, Lerner College of Medicine; Andrology Laboratory; Center for Reproductive Medicine, Infertility and Sexual Function, Glickman Urological Institute, Center for Advanced Research in Human Reproduction, The Cleveland Clinic Foundation, Cleveland, Ohio, USA, Cleveland Clinic, Ohio, USA, Lerner College of Medicine, Center for Reproductive Medicine, Infertility and Sexual Function, Glickman Urological Institute, Center for Advanced Research in Human Reproduction, The Cleveland Clinic Foundation, Cleveland, Ohio, USA, Cleveland Clinic and Case Western Reserve University, Cleveland, Ohio, USA, Lerner College of Medicine; Androl
2. Center for Reproductive Medicine, Cleveland Clinic 9500 Euclid Avenue, Desk A19.1 Cleveland, Ohio 44195 USA
Chapter keywords

Abstract

The growing trend of male factor infertility incidences, along with a decrease in sperm quality over recent years, is a cause for concern. Intracytoplasmic sperm injection (ICSI) and other assisted reproductive technologies have provided patients with an alternative to their infertility woes by mimicking natural fertilization in the laboratory. However, because ICSI bypasses the initial pathological cause for infertility, possible transmission of genetic defects can occur. In addition, a relatively low live-birth rate is still associated with ART. Further development in the understanding of gamete maturation and fertilization still needs to be elucidated. In order to optimize the outcomes of ART, all aspects of natural reproduction must be understood, including fertilization, gamete maturation and embryonic development.

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