Clinical anatomical correlation as well as functional studies with PET SPECT, Functional MRI magneto encephalography and atomic force microscopy reveal that distributed network form the anatomical basis of behavioral Neurology. A lesion in varied areas of the brain may destroy a functional network which may cause a specific deficit, nevertheless it is still useful to assign major functions to specific anatomical areas of the brain. Many anatomical, pathological and clinical correlates have withstood test of time but the underlying mechanisms have changed. Therefore discharge from one area of brain if severe and persistent may damage its homologous area or another part of distributed network by Glutamate-NMDA excitatory mechanism, induction, of apoptosis from intracellular calcium disregulation or neural plasticity induced by early response of genes.