This chapter is an extension of communication which has a strong focus extensively on the relationship between a nurse and the patient. Besides, describing the dimensions of therapeutic relationship, phases of interpersonal relationship has been greatly elaborated without compromising the aspect of cultural influence. The elaboration has extended its horizon with the concept of transactional analysis. The explanation of interpersonal relations in the context of Peplau’s theory has not only facilitated understanding but also it is extended to improve understanding but also a it is extended to improve understanding between individuals within team or in a group setting with aid of JOHARI window. The barriers to effective interpersonal communication and strategies to overcome the same have fulfilled its comprehensibility.