There are no standard guidelines regarding medications in cataract surgery. Different centers follow different protocols; however antibiotics, povidone–iodine, NSAIDS and steroid are the mainstay. Antibiotics can be administered topically (most common route), subconjunctival (at the end of surgery) intra cameral (still controversial) or intravitreal. Intravenous antibiotics are rarely required. Povidone iodine is an iodine releasing polymer, whose single pre-op application is as effective as 3 days pre-op antibiotics instillation. Other drugs like NSAIDS and steroids are used postoperatively to reduce the anterior chamber reaction. Both are equally efficacious for the purpose. However steroid tends to increase the IOP. Newer steroids like vimex olene and loteprednol are less likely to cause postoperative rise of IOP. An intraocular biodegradable polymer dexamethasone drug delivery system (DEXDDS) is being developed, to make the patient free of steroid.