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Chapter-23 Clinical Enzymology and Biomarkers

BOOK TITLE: Textbook of Biochemistry for Medical Students

Author
1. Vasudevan DM
2. S Sreekumari
3. Vaidyanathan Kannan
ISBN
9789350250167
DOI
10.5005/jp/books/11359_23
Edition
6/e
Publishing Year
2011
Pages
8
Author Affiliations
1. Faculty of Medicine, Amrita Vishwa Vidyapeetham, (Amrita University), Kochi, Kerala, Formerly Principal, College of Medicine, Amrita, Kerala; Formerly, Dean, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, Amrita Vishwa Vidyapeetham (Deemed University), Cochin, Kerala, E-mail: dmvasudevan@aims.amrita.edu, PG Programs and Research College of Medicine, Amrita Institute of Medical Sciences, Kochi, Kerala, India, College of Medicine, Amrita Institute of Medical Sciences, Kochi, Kerala, India; Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India
2. Jubilee Mission Medical College, Trissur, Kerala, Sree Gokulam Medical College and Research Foundation, Thiruvananthapuram, Kerala, India, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India, Government Medical College, Thrissur and Thiruvananthapuram, Kerala, India; Sree Gokulam Medical College and Research Foundation, Thiruvananthapuram, Kerala, India; Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India
3. Amrita Institute of Medical Sciences, Kochi, Kerala, India, Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla, Kerala, India, Believers Church Medical College and Hospital, Thiruvalla, Kerala, India
Chapter keywords

Abstract

Clinically useful enzymes in diagnosis and prognosis of myocardial infarction are CK, CTI/CTT, AST and LDH. ALT, AST, ALP, GGT and NTP are clinically useful markers in hepatic diseases. ALP is also a useful marker in bone diseases. GGT is used an indicator of alcohol abuse and as a marker of alcoholic liver cirrhosis. ACP and PSA are used in the diagnosis of prostate cancer. PSA values higher than 10 mg/L is indicative of prostate cancer. Cholinesterase (ChE) is used as a marker in organophosphorus insecticide poisoning. Pancreatic amylase is a marker of acute pancreatitis. Therapeutically useful enzymes are streptokinase or urokinase, asparaginase, hyaluronidase, alpha1 antitrypsin, pepsin and trypsin. Some examples of enzymes used in diagnostic methods are peroxidase, glucose oxidase and alkaline phosphatase.

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