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Chapter-08 Rationale Use of Chemotherapy, Radiotherapy and Hormone Therapy

BOOK TITLE: Changing Paradigm in Breast Cancer Management

Author
1. Mehta Ajay
ISBN
9789350250495
DOI
10.5005/jp/books/11247_8
Edition
1/e
Publishing Year
2011
Pages
16
Author Affiliations
1. Nowrosjee Wadia Maternity Hospital, Mumbai, Maharashtra, India, Central India Cancer Research Institute, Nagpur, Maharashtra, India
Chapter keywords

Abstract

It is important to recognize the common hereditary cancer syndromes. These include not only those related to BRCA1 and BRCA2 mutations, but also other genes whose roles have yet to be fully defined. For example, CDH1 mutations are associated with a lifetime breast cancer risk of about 40%, as well as with diffuse gastric carcinomas, and CDH1-related carcinomas are usually of lobular histology. The lifetime risk of breast cancer for individuals affected with Peutz-Jeghers syndrome is 45%. The role of CHK2 mutations has yet to be fully defined, and routine testing for these is not recommended at this time. Patients with Li-Fraumeni syndrome have a higher incidence of radiation-induced cancers, and consideration should be given to mastectomy rather than breast-conserving therapy and radiation for the treatment of early breast cancers in carriers of this mutation. Polymorphisms in fibroblast growth factor receptor type 2 (FGR2) and trinucleotide repeat containing 9 (TNRC9) are significant genetic risk factors for breast cancer.

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