The ozone sterilization process, however, requires only medical-grade oxygen, and only oxygen and water are released into the air when the sterilization process is completed. There have been many barriers to success with ozone included its instability and difficulties in generating ozone in its pure form. How quickly ozone sterilization might be adopted is unknown. ETO is a process that device manufacturers are very familiar with, and it is well known what materials will work with it. Gas plasma systems, known for short cycle times, have been on the market for 10 years, in which time about 6000 units have been placed in over 40 countries. In addition to claims that the ozone technology is safer and more environmentally friendly than ETO, it is also touted to have its potential cost savings. However, when considering financial benefits, device companies and hospitals also need to consider installation costs, cycle times and their effect on inventory, compatibility with commonly used materials, throughput, and additional services the process vendor might provide. TSO3’s first ozone sterilizer is a 125 litres chamber version and is intended for hospital sterilization applications.