This chapter provides detail description of Skeletal fluorosis. Chapter has 31 well illustrated diagrams and pictures. Skeletal fluorosis, incidence of fluorosis in different states of India, metabolism of fluoride, sources of fluoride, total daily fluoride intake, absorption of fluorides, distribution of fluorides, excretion of fluorides, clinical features of fluoride intoxication, dental fluorosis, skeletal fluorosis, neurological manifestations of skeletal fluorosis, laboratory investigations of fluorosis, fluoride estimations, pathology of fluorosis, gross changes in the skeleton, histopathology of bones, muscle pathology, nerve pathology, spinal cord studies, differential diagnosis of fluorosis, treatment of fluorosis, surgical management of skeletal fluorosis with neurological manifestations are described in detail. 2 tables are included to highlight incidence of fluoride in water resource of India and urinary fluoride levels in endemic flourotic patients. 112 references are included at the end of the chapter to facilitate further reading.