Salmonella osteomyelitis accounts for approximately 10% of all hematogenous infections of the bone. Osteomyelitis, a well-known complication in children with sickle cell disease, is seldom appreciated as a cause of osteomyelitis in previously healthy children. Salmonella spondylitis, a complication of typhoid fever, was first described by Sir James Paget in 1876. S. typhi spondylitis is uncommon (<1%) and affects mainly the lower thoracic and lumbar spine and infrequently the sacroiliac joints may be involved. Brucellosis is a systemic infection caused by gram-negative bacilli of the genus Brucella, which may involve multiple organs and tissues. Osteoarticular involvement is a common complication of brucellosis. The lumbar spine is frequently affected and patients may present with back pain and neurological deficit.