Dentofacial orthopedics deals with the diagnosis and treatment of skeletal disproportions. It is imperative to comprehend the features, both intra oral and extra oral, of skeletal disproportions in three planes of space. This chapter outlines the growth pattern in skeletal malocclusions and the sexual dimorphism of such disproportions. This particular topic has been provided as a separate chapter to help the postgraduate orthodontic scholar understand the etiology, clinical features and growth patterns of skeletal malocclusion.