This chapter are dedicated to theory of histopathology of bones, joints and soft tissues. Coloured diagrams and pictures of histopathology of bones, joints and soft tissues are given in detail. A brief write up about contents of chapter is given as introduction in the beginning of the chapter. Normal histology of bones, joints and soft tissues is described initially to provide the basis for better understanding of histopathology. Histopathology of Bones, developmental disorders, osteopetrosis, osteomalacia, pagets disease, osteomyelitis, osteoma, osteosarcoma, chondrosarcoma, Giant cell tumor, arthritis, gout, lipoma, dermoid, rhebdomyosarcoma is described in detail with the help of 29 well illustrated diagrams.