Pathophysiology and management of entrapment syndromes in general followed by discussions on common nerve entrapment syndromes are discussed in this chapter. Entrapment neuropathy refers to isolated peripheral nerve injuries that occur at specific locations where there is either intermittent or constant mechanical constriction. They are common in neurological practice. The ability to recognize nerve entrapment syndromes and to distinguish them from other diseases of peripheral nerve is important. Paresthesias, pain, or progressive weakness or muscle wasting, or any combination of these in the distribution of a single peripheral nerve are the cardinal findings.