Continuous positive airway pressure (CPAP) is a treatment in which air is slightly pressurized and provided to the patient throughout the breathing cycle. CPAP is needed by infants with a number of respiratory conditions and by very low birth weight infants (VLBWIs). It is widely used in neonatology as an alternative to intubation and mechanical ventilation. Nasal CPAP (nCPAP) is administered through the nose. Bubble CPAP systems consists of: (i) Pressure manifold, (ii) Air and O2 Blender, (iii) MR290 humidification chamber, (iv) Single-heated breathing circuit, (v) CPAP generator, and (vi) Patient interface.