This chapter provides detail description of Intravenous Immunoglobulin and biologicals in childhood dermatoses. Intravenous immunoglobulin (IG) therapy, preparation for intravenous (IV) therapy, mechanism of action of IV therapy, indications of IVIG, uses of IVIG in childhood dermatoses, biological agents, classification of biologicals, tumor necrosis factor-α and anti TNF-α biologicals, anti TNF-α for pediatric dermatoses and other biologicals used for children dermatoses are described in detail. 2 tables are included to highlight indications and uses of IVIG. 25 references are included at the end of the chapter to facilitate further reading.