Chapter-08 Clinical Development of Anticancer Molecules
BOOK TITLE: Drug Discovery and Clinical Research
Author
1. Mishra SK
ISBN
9789350252727
DOI
10.5005/jp/books/11216_8
Edition
1/e
Publishing Year
2011
Pages
27
Author Affiliations
Chapter keywords
Anticancer molecules,
investigational new drug (IND),
tumor angiogenesis,
hollow fiber assay,
subcutaneous xenografts,
breast carcinoma,
lung carcinoma,
glioma,
methylthiazoldiphenyl tetrazolium (MTT) assay,
colony-forming assay,
tumor clonogenic assay (TCA),
diagnostic biomarker,
prognostic biomarker,
phase 0 clinical trials,
myelosuppression,
mucositis,
radiotherapy,
drug discovery,
NDA filing,
COMPARE program,
SF-268,
LC50,
Xenograft tumors,
biomarkers,
pharmacokinetics,
toxicology studies,
chemistry,
manufacturing and control,
emergency use IND,
cytotoxic drugs,
starting dose selection,
surrogate end-points,
anticancer agents,
EORTC,
progression free survival,
complete response,
fast track approval,
orphan drug approvals,
phase IV studies