This chapter provides detail description of Burn wound infection. Chapter has 33 well illustrated diagrams and pictures. Burn wound infection, classification of microbial status of burn wound, diagnosis of burn wound infection, systemic signs of burn wound infection, pseudomonas invasive sepsis and septic embolization, nodular satellite lesion, nodulopapular lesions, streptococcal burn wound infection and gram negative sepsis are described in detail with the help of coloured pictures. 4 boxes are included to highlight terminology used in burn wound infection, classification of microbial status of burn wound, diagnosis of burn wound infection and systemic signs of burn wound infection.