Antifungal agents in dentistry are described in detail. All topics covered in this chapter are given in a box in the beginning of the chapter. Salient features of each topic are given in 4 tables for easy learning. Antifungal agents, topical antifungal agents, systemic antifungal agents, amphotericin B, Nystatin are described in detail. Different dental conditions for which antifungal agents are used given in 9 boxes. 13 references are given at the end of the chapter for further reading.