Obstetrics & Gynecology: Recurrent Miscarriage

by Mala Arora, Siladitya Bhattacharya, Vijaya Kumari

This book “World Clinics: Obstetrics and Gynecology: Recurrent Miscarriage” comprises of total 12 chapters. The first chapter provides an introduction on recurrent miscarriage (RM). In this chapter, the author questions the traditional definition of recurrence based on three consecutive episodes of early pregnancy loss. Second chapter review the association of antiphospholipid syndrome (APS) and RM. Third chapter focuses on the screening and management of thrombophilia in RM. Hyperhomocysteinemia (Hhcy) is a metabolic disorder which is associated with increased risk of vascular disease. Incidences of Hhcy in RM are discussed in the fourth chapter. Fifth chapter covers the association of obesity with spontaneous miscarriage in the general population, women who conceive following fertility treatment and women with polycystic ovary syndrome (PCOS). The role of minimally invasive surgical treatments for recurrent miscarriage due to uterine pathology are described in sixth chapter. Pregnancy loss and bacterial vaginosis (BV) are discussed in seventh chapter. Eighth chapter explores the association between endometritis and RM. A comprehensive discussion on the genetic causes of RM has been provided in the ninth chapter. Tenth chapter presents a review on the role of different IVF protocols, role of antiphospholipid antibodies, overcoming the male factor, recurrent implantation failure, role of oocyte donation and surrogacy. Eleventh chapter focuses on the application of preimplantation genetic screening (PGS) in patients who suffer from RM due to genetic abnormalities or idiopathic causes. The last chapter suggests that advances in the technology and development of new techniques could now provide the opportunity to examine the complete chromosome complement and increase diagnostic accuracy and identify embryos which are normal.

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