This chapter provides detail description of the role of intrauterine insemination in low resource settings. Chapter has 1 well illustrated diagram and picture. Factors affecting IUI success rates, IUI versus ART: cost effectiveness is described in detail. 6 tables are included to highlight indications of IUI, factors affecting IUI success rate, pregnancy rate in IUI, pregnancy rate and duration of infertility and cost effectiveness of various infertility treatment. One flow chart is added to depict algorithm for patient selection in IUI program. 27 references are included at the end of the chapter to facilitate further reading.