This chapter provides detail description of FNAC in lesions bones. Chapter has 9 well illustrated diagrams and pictures. Classification of bone lesions, osteosarcoma, chondrosarcoma, giant cell tumor of bone, chondroblastoma, chordoma, Ewing’s sarcoma, langerhans cell histiocytosis are described in detail with the help of excellent illustrations and histopathological pictures. All salient features of different lesions are highlighted in 8 boxes. 4 tables are included to provide details of classification of bone lesions, differential diagnosis of giant cell tumor and small round cell tumor for easy learning. 26 references are included at the end of the chapter to facilitate further reading.