This chapter provides detail description of head, neck, orbit and salivary glands. Chapter has 20 well illustrated diagrams and pictures. Cysts in the head and neck region, neoplastic lesions, salivary gland lesions, neoplasms of salivary glands, malignant tumors of salivary glands and orbital lesions are described in detail with the help of excellent illustrations and histopathological pictures. All salient features of different lesions are highlighted in 18 boxes. 5 tables are included to provide details of cysts in head and neck region, differential diagnosis of cervical paraganglioma, differential diagnosis of adenoid cyst carcinoma and acinic cell carcinoma for easy learning. 48 references are included at the end of the chapter to facilitate further reading.