This chapter provides detail description of FNAC in lesions of liver, spleen, pancreas and gastrointestinal tract. Chapter has 16 well illustrated diagrams and pictures. Liver lesions, benign neoplastic lesions of liver, immunocytochemistry of hepatocellular carcinoma, metastatic adenocarcinoma, cholangiocarcinoma, hepatoblastoma, metastatic malignancies, pancreatic acinar carcinoma, neuroendocrine tumor, gastrointestinal tumor, signet ring cell adenocarcinoma are described in detail with the help of excellent illustrations and histopathological pictures. All salient features of different lesions are highlighted in 10 boxes. 5 tables are included to provide details of common space occupying lesions in liver, immunohistochemistry of hepatocellular carcinoma, difference between hepatocellular carcinoma and adenocarcinoma and chronic pancreatitis vs. adenocarcinoma for easy learning. 24 references are included at the end of the chapter to facilitate further reading.