This chapter provides detail description of sonography of abdomen: Focal lesions in liver. Chapter has 41 well illustrated diagrams and pictures. Simple liver cyst, echinococcal cyst, liver abscess, amebic liver abscess, progenic liver abscess, tubercular liver abscess, hepatic trauma, benign liver masses and malignant tumors seen on ultrasound of liver are described in detail with the help of excellent ultrasonographic illustrations and pictures. 26 references are given at the end of the chapter for further reading.