This chapter provides detail description of sonography of abdomen: Pancreas and spleen. Chapter has 37 well illustrated diagrams and pictures. Normal pancreas and anatomy, acute pancreatitis, chronic pancreatitis, pancreatic trauma, normal spleen and anatomy, polysplenia, wandering spleen, splenic cyst, splenic abscess, splenic trauma, storage diseases, malignant masses seen on ultrasound of pancreas and spleen are described in detail with the help of excellent ultrasonographic illustrations and pictures. 34 references are given at the end of the chapter for further reading