This chapter provides detail description of female sexuality and androgens. Female sexuality, androgen production in females, major androgens, their production, plasma levels and importance, physiology of androgens in life cycle, sexual effect of sudden complete loss of ovarian androgens in women, androgens insufficiency syndrome in females are given in detail. 2 tables are included to highlight major androgens in female, their production and plasma levels and various commercial preparations of androgens. Two flow charts are added to depict metabolism of androgens and sudden complete loss of ovarian androgens on women’s sex cycle. 57 references are included at the end of the chapter to facilitate further reading.