This chapter provides detail description of abnormal vaginal discharge. Normal or physiological vaginal discharge, abnormal or pathological vaginal discharge, leukorrhea, trichomonas vaginitis, vaginal thrush, chlamydial infections, gonorrhoea, herpes genitalis, senile vaginitis, idiopathic vaginal discharge, syndromic approach and investigations for vaginal discharge are given in detail. One flow chart is added to depict syndromic vaginal discharge. 20 references are included at the end of the chapter to facilitate further reading.