This chapter provides detail description of nitric oxide: A challenging radical. Role of nitric oxide as reactive oxygen species, role of nitric oxide as reactive oxygen species in preeclampsia, role of nitric oxide as reactive oxygen species in premature rupture of membrane, role of nitric oxide as reactive oxygen species in preterm labor, role of nitric oxide in idiopathic recurrent miscarriage are described in detail. 26 references are included at the end of the chapter to facilitate further reading.