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Chapter-02 Epidemiology and Magnitude of the Problem

BOOK TITLE: Retinoblastoma

Author
1. Ramasubramanian Aparna
2. Shields Carol L
ISBN
9789350257845
DOI
10.5005/jp/books/11629_2
Edition
1/e
Publishing Year
2012
Pages
6
Author Affiliations
1. Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA, Moran Eye Center, University of Utah, Salt Lake City, Utah, USA
2. Wills Eye Institute, Philadelphia, Pennsylvania, USA, Wills Eye Hospital, Philadelphia, USA, Wills Eye Institute, Thomas Jefferson University, Philadelphia, PA, U.S.A
Chapter keywords

Abstract

Retinoblastoma is the most common intraocular tumor of childhood and represents 11% of cancers developing in the first year of life, but accounts for only 3% of the cancers developing among children younger than 15 years of age. The incidence of retinoblastoma is estimated to be 1:16,000-1:18,000 live births. Multiple environmental factors are being investi­gated for the causation of retinoblastoma, the most important of which is radiation exposure. The survival from retinoblastoma varies from lesser than 95% in developed countries to 30-50% in developing countries. In developed countries, the secondary goals of retinoblastoma management are gaining focus which includes reducing incidence of second cancers, increasing globe salvage, improving visual outcomes and improving quality of life. Early diagnosis and appropriate management are of pivotal importance and hence efforts must be undertaken to strengthen the retinoblastoma programs in developing countries.

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