This chapter provides detail description of amputations of the foot and ankle. Chapter has 8 well illustrated diagrams and pictures. Indications for amputation, level of amputation, contraindications to lower extremity salvage after trauma, multidisciplinary care, psychosocial aspects and surgical techniques of amputation are described in detail. 4 tables are included to highlight contraindications of lower extremity salvage after trauma, threshold predictors for wound healing, phases of physical therapy after amputation and postoperative dressing protocol for Syme and transtibial amputations. 55 references are included at the end of the chapter to facilitate further reading.