Head and neck cancer is characterized as malignant tumors and most of these tumors are found to be squamous cell carcinoma. Mucositis-related pain is mostly experienced by patients and Pain which is caused by cancer treatments should be studied thoroughly for developing suitable treatments. Pain is identified mostly at the time of diagnosis and it depends on the tumor stage and bone involvement. Vinca alkaloids cause neurotoxicity which may lead to pain. Cisplatin may cause loss of large myelinated nerve fibers by neuronal death. Bisphosphonates is a drug used in the bone cancer and it may cause non-healing bony lesions and acute pain. Surgical treatment also causes negative effects on patients after surgery. Pain should be assessed as it has impact on daily life. Sentinel node biopsy is the first surgical procedure. Oral mucositis is the reason for pain in chemotherapy and radiotherapy. Systemic medications, breakthrough pain and adjuvant analgesics are pharmacological management of pain in HNC. Cognitive behavioral therapy and massage therapy can also be used in the management of HNC pain.