Phantom limb pain usually presents within the first week after amputation. Patients often describe their pain as burning, crushing, or feeling like they have been stabbed with needles in the missing limb. The main pathophysiology of phantom limb pain is unknown. There are three primary theorized mechanisms including peripheral, spinal plasticity and cerebral reorganization which explain phantom limb pain. Clinical examination of phantom limb pain includes signs of skin abrasions, blisters or breakdown etc. Signs of local infection should be investigated. For phantom limb pain, there are no specific diagnostic criteria, but differential diagnostic procedures are followed for the investigation of phantom limb pain. Multiple medications have been used for the treatment of phantom limb pain. Commonly, antidepressants and anticonsultants used to treat neuropathic pain of phantom limb. Surgical treatment is performed only when it is found that the stump has not healed properly.