This chapter provides detail description of anesthesia for fracture mandible. The chapter has 7 well illustrated diagrams and pictures. General anesthesia, local anesthesia, middle superior alveolar nerve block, anterosuperior alveolar nerve block, greater palatine nerve block, lower jaw infiltration, inferior alveolar nerve block, buccal nerve block and mental nerve block are described in detail. Summary of chapter is given in a box at the end of the chapter for better understanding.