This chapter provides detail description of rheumatic fever. Chapter has 11 well illustrated diagrams and pictures. Rheumatic fever, carditis, arthritis, chorea, erythema marginatum, subcutaneous nodules, laboratory criteria for diagnosis, major criteria, minor criteria sign and symptoms, predisposing factors, pathogenesis, investigations, treatment, complications, treatment of complications and prevention are described in detail. 27 references are included at the end of the chapter to facilitate further reading.